ChloroquineV1, France, Analysis, bibRecord, 000328

Probing the role of the covalent linkage of ferrocene into a chloroquine template

Identifieur interne : 000328 ( France/Analysis ); précédent : 000327; suivant : 000329

Probing the role of the covalent linkage of ferrocene into a chloroquine template

Auteurs : Christophe Biot [France] ; Wassim Daher [France] ; Cheikh M. Ndiaye [France] ; Patricia Melnyk [France] ; Bruno Pradines [France] ; Natascha Chavain [France] ; Alain Pellet [France] ; Laurent Fraisse [France] ; Lydie Pelinski [France] ; Christian Jarry [France] ; Jacques Brocard [France] ; Jamal Khalife [France] ; Isabelle Forfar-Bares [France] ; Daniel Dive [France]

Source :

Journal of Medicinal Chemistry [ 0022-2623 ] ; 2006.

RBID : Hal:hal-00097346

Abstract

A new therapeutic approach to malaria led to the discovery of ferroquine (FQ). To assess the importance of the linkage of the ferrocenyl group to a 4-aminoquinoline scaffold, two series of 4-aminoquinolines, structurally related to FQ, were synthesized. Evaluation of antimalarial activity, physicochemical parameters, and Β-hematin inhibition property indicate that the ferrocene moiety has to be covalently flanked by a 4-aminoquinoline and an alkylamine. Current data reinforced our choice of FQ as a drug candidate.

Url:

https://hal.archives-ouvertes.fr/hal-00097346

DOI: 10.1021/jm060259d

Affiliations:

France

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000200
to stream Hal, to step Curation: 000200
to stream Hal, to step Checkpoint: 000231
to stream Main, to step Merge: 001C19
to stream Main, to step Curation: 001C08
to stream Main, to step Exploration: 001C08
to stream France, to step Extraction: 000328

Links to Exploration step

Hal:hal-00097346

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en">Probing the role of the covalent linkage of ferrocene into a chloroquine template</title>
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<author><name sortKey="Daher, Wassim" sort="Daher, Wassim" uniqKey="Daher W" first="Wassim" last="Daher">Wassim Daher</name>
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<author><name sortKey="M Ndiaye, Cheikh" sort="M Ndiaye, Cheikh" uniqKey="M Ndiaye C" first="Cheikh" last="M. Ndiaye">Cheikh M. Ndiaye</name>
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<author><name sortKey="Khalife, Jamal" sort="Khalife, Jamal" uniqKey="Khalife J" first="Jamal" last="Khalife">Jamal Khalife</name>
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<author><name sortKey="Dive, Daniel" sort="Dive, Daniel" uniqKey="Dive D" first="Daniel" last="Dive">Daniel Dive</name>
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<idno type="DOI">10.1021/jm060259d</idno>
<series><title level="j">Journal of Medicinal Chemistry</title>
<idno type="ISSN">0022-2623</idno>
<imprint><date type="datePub">2006</date>
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<front><div type="abstract" xml:lang="en">              <p>A new therapeutic approach to malaria led to the discovery of ferroquine (FQ). To assess the importance of the linkage of the ferrocenyl group to a 4-aminoquinoline scaffold, two series of 4-aminoquinolines, structurally related to FQ, were synthesized. Evaluation of antimalarial activity, physicochemical parameters, and Β-hematin inhibition property indicate that the ferrocene moiety has to be covalently flanked by a 4-aminoquinoline and an alkylamine. Current data reinforced our choice of FQ as a drug candidate.</p>
            </div>
</front>
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<name sortKey="Dive, Daniel" sort="Dive, Daniel" uniqKey="Dive D" first="Daniel" last="Dive">Daniel Dive</name>
<name sortKey="Forfar Bares, Isabelle" sort="Forfar Bares, Isabelle" uniqKey="Forfar Bares I" first="Isabelle" last="Forfar-Bares">Isabelle Forfar-Bares</name>
<name sortKey="Fraisse, Laurent" sort="Fraisse, Laurent" uniqKey="Fraisse L" first="Laurent" last="Fraisse">Laurent Fraisse</name>
<name sortKey="Jarry, Christian" sort="Jarry, Christian" uniqKey="Jarry C" first="Christian" last="Jarry">Christian Jarry</name>
<name sortKey="Khalife, Jamal" sort="Khalife, Jamal" uniqKey="Khalife J" first="Jamal" last="Khalife">Jamal Khalife</name>
<name sortKey="M Ndiaye, Cheikh" sort="M Ndiaye, Cheikh" uniqKey="M Ndiaye C" first="Cheikh" last="M. Ndiaye">Cheikh M. Ndiaye</name>
<name sortKey="Melnyk, Patricia" sort="Melnyk, Patricia" uniqKey="Melnyk P" first="Patricia" last="Melnyk">Patricia Melnyk</name>
<name sortKey="Pelinski, Lydie" sort="Pelinski, Lydie" uniqKey="Pelinski L" first="Lydie" last="Pelinski">Lydie Pelinski</name>
<name sortKey="Pellet, Alain" sort="Pellet, Alain" uniqKey="Pellet A" first="Alain" last="Pellet">Alain Pellet</name>
<name sortKey="Pradines, Bruno" sort="Pradines, Bruno" uniqKey="Pradines B" first="Bruno" last="Pradines">Bruno Pradines</name>
</country>
</tree>
</affiliations>
</record>

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{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     Hal:hal-00097346
   |texte=   Probing the role of the covalent linkage of ferrocene into a chloroquine template
}}

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	Serveur d'exploration Chloroquine
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Serveur d'exploration Chloroquine

Probing the role of the covalent linkage of ferrocene into a chloroquine template

Probing the role of the covalent linkage of ferrocene into a chloroquine template

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Abstract

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